The role of the South Node ( Ketu ) in Horoscopy 

South Node's Effects in the 12 Houses

Ketu in the Ascendant

Ketu in the Ascendant makes one intelligent and endowed with fortune. Will be quarrelsome, will have less wealth, will  be melancholic and will have the ability to make others quarrel.  But if Ketu is in the signs of Capricorn or Aquarius these effects will be invalid as he is powerful in these signs. 

Ketu in the Second House 

Will be loquacious , will be devod of eduation and will have a crooked look. Will be learned and will crave for others' wealth.

Ketu in the Third House

Will be noble and charitable. Will be valorous and adventurous.Will love evil people. Will destroy enemies and will enjoy wealth, prosperity and all sorts of enjoyments. Will be a genius of a high order. Will be versatile and will destroy opposition.

Ketu in the Fourth House

Medical Astrology postulates that heart may be afflicted if any malefic is posited in the fourth. ( As the Fourth House rules the heart ). Will be devoid of happiness, landed properties, relatives and conveyances. All relatives will become your enemies. This position of the South Node is detrimental to getting legacy from mother.

Ketu in the Fifth House

Will be cruel, will possess an adamantine will & will not get much happiness from progeny. WIll have disorders of the digestive tract. Will be afflicted by many a disease. Will love sin and will be devoid of happiness. 

Ketu in the Sixth House 

Medical Astrology postulates that if a malefic is posited in the sixth, stomach disorders will haunt the native. Will be the leader of your community, Will have high education and will be endowed with many a virtue. Will love relatives. Will be proud and vainglorious. Will have allround knowledge
and liberality.

Ketu in the Seventh House

Will be devoid of happiness from spouse and will love women of dubious character. Will be devoid of prosperity. Will be melancholic and will be a Machiavelli. Will love travel and will land in roublesome situations. 

Ketu in the Eighth House

Will be intelligent and will have high concentration. Will be afflicted by weapons. Will not have much longevity. Will love other's wealth and women. Will be miserly. Will be famous and will have adership qualities. This position of the South Node in the eighth indicates Karmic backlog.

Ketu in the Ninth House

Will be sinful, poor and will be devoid of paternal happiness.Will be lustful and will not have much penchant for Religion and Morality. Will be a Kapha-type, in ayurvedic terminology.Will be proud and chivalrous. Will criticise the noble and will lower himself by committing heinous acts.

Ketu in the Tenth House

Will love people and will earn the name of philanthropist.Will be quite rich and will have philosophic ability. Will be good in sculpturing. Will be efficient, famous and endowed with professional skill. This dominance of the South Node on the Meridien is good for professional enhancement.

Ketu in the Eleventh House

Will be wealthy with high education. Will have fame and altruistic merit. Will enjoy the pleasures of the mundane a lot. Will be versatile endowed with many good qualities. Will be liberal and generous. Will be very popular because of philanthropic deeds.

Ketu in the Twelfth House

Will be fickle and ever changing. Eyes may be afflicted. Will be fond of travel. Will try to conceal sins. Will be sorrowful and melancholic.Will have dubious character. But this position of the South Node is conducive to immense occult power as Ketu represents the Occult.